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Identification of the Active Catalyst for Nickel‐Catalyzed Stereospecific Kumada Coupling Reactions of Ethers
Author(s) -
Dawson David D.,
Oswald Victoria F.,
Borovik Andy S.,
Jarvo Elizabeth R.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000215
Subject(s) - stereospecificity , catalysis , nickel , chemistry , alkyl , catalytic cycle , coupling reaction , redox , combinatorial chemistry , organic chemistry
Abstract A series of nickel complexes in varying oxidation states were evaluated as precatalysts for the stereospecific cross‐coupling of benzylic ethers. These results demonstrate rapid redox reactions of precatalysts, such that the oxidative state of the precatalyst does not dictate the oxidation state of the active catalyst in solution. These data provide the first experimental evidence for a Ni 0 –Ni II catalytic cycle for a stereospecific alkyl–alkyl cross‐coupling reaction, including spectroscopic analysis of the catalyst resting state.