Premium
A Sunscreen‐Based Photocage for Carbonyl Groups
Author(s) -
LinerosRosa Mauricio,
Miranda Miguel A.,
LhiaubetVallet Virginie
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000123
Subject(s) - photoprotection , photochemistry , carbonyl group , chemistry , chromophore , sunscreening agents , combinatorial chemistry , stereochemistry , biochemistry , medicine , photosynthesis , cancer , skin cancer
Photolabile protecting groups (PPGs) have been exploited in a wide range of chemical and biological applications, due to their ability to provide spatial and temporal control over light‐triggered activation. In this work, we explore the concept of a new photocage compound based on the commercial UVA/UVB filter oxybenzone (OB; 2‐hydroxy‐4‐methoxybenzophenone) for photoprotection and controlled release of carbonyl groups. The point here is that oxybenzone not only acts as a mere PPG, but also provides, once released, UV photoprotection to the carbonyl derivative. This design points to a possible therapeutic approach to reduce the severe photoadverse effects of drugs containing a carbonyl chromophore.