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Cover Feature: Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria (Chem. Eur. J. 13/2020)
Author(s) -
Frei Angelo,
Amado Maite,
Cooper Matthew A.,
Blaskovich Mark A. T.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000121
Subject(s) - rhenium , chemistry , mutant , cover (algebra) , mode of action , colistin , bacteria , antibacterial activity , antibiotics , combinatorial chemistry , microbiology and biotechnology , biology , biochemistry , inorganic chemistry , genetics , mechanical engineering , engineering , gene
The synthesis and characterization of a blue‐light‐activated rhenium tricarbonyl complex with antibacterial activity against methicillin resistant S. aureus and colistin resistant E. coli are described. Distinct activity profiles are observed in the presence and absence of light. Cellular uptake experiments in different E. coli mutants and synergy experiments with other antibiotics point to two distinct modes of action. More information can be found in the Full Paper by A. Frei, M. A. T. Blaskovich, et al. on page 2852.