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Frontispiece: Innovative Linker Strategies for Tumor‐Targeted Drug Conjugates
Author(s) -
Dal Corso Alberto,
Pignataro Luca,
Belvisi Laura,
Gennari Cesare
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201986561
Subject(s) - cytotoxic t cell , linker , bioorthogonal chemistry , conjugate , drug , tumor microenvironment , pharmacology , tumor cells , concomitant , chemistry , cancer research , cytotoxicity , medicine , combinatorial chemistry , biochemistry , computer science , in vitro , click chemistry , mathematical analysis , mathematics , operating system
Improvement of the pharmacological effects of cytotoxic agents with a concomitant decrease of systemic toxicity has been investigated for decades in order to reduce the side effects of tumor‐targeting drugs. In their Review article, A. Dal Corso and C. Gennari et al. highlight recent advances on the different modalities to promote the selective release of cytotoxic agents, either by exploiting specific hallmarks of the tumor microenvironment (e.g. pH, enzyme expression) or by the application of external triggers (e.g. light and bioorthogonal reactions) on page 14740 ff.