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Frontispiece: High‐Field MRI Contrast Agents and their Synergy with Optical Imaging: the Evolution from Single Molecule Probes towards Nano‐architectures
Author(s) -
Harris Michael,
Biju Silvanose,
ParacVogt Tatja.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201986161
Subject(s) - nanotechnology , contrast (vision) , supramolecular chemistry , materials science , magnetic resonance imaging , nano , nanoparticle , nuclear magnetic resonance , field (mathematics) , relaxation (psychology) , molecule , computer science , chemistry , medicine , physics , radiology , biology , artificial intelligence , neuroscience , mathematics , organic chemistry , pure mathematics , composite material
The application of contrast agents for high‐field MRI , which range from single molecules to nanoparticles, is examined by T. N. Parac‐Vogt and co‐workers in this Minireview on page 13838 ff. Emerging high‐field MRI applications require the development of novel contrast agents that exhibit high relaxation enhancement as a function of magnetic field strength. Paramagnetic ions such as Dy 3+ , Tb 3+ or Ho 3+ incorporated into supramolecular or inorganic nano‐architectures represent promising platforms for the development of high field MRI contrast agents. Furthermore, such platforms allow facile inclusion of multiple imaging modalities, therapeutic loading, and targeting vectors.