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Frontispiece: Targeting G‐Rich DNA Structures with Photoreactive Bis‐Cyclometallated Iridium(III) Complexes
Author(s) -
Weynand Justin,
Bonnet Hughes,
Loiseau Frédérique,
Ravanat JeanLuc,
Dejeu Jérôme,
Defrancq Eric,
Elias Benjamin
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201985563
Subject(s) - iridium , guanine , dna , chemistry , g quadruplex , electron transfer , stereochemistry , computational biology , biochemistry , photochemistry , biology , gene , catalysis , nucleotide
G‐rich DNA structures are of great importance, notably in the telomeric region where G‐quadruplex DNA plays a key role in the development of cancer. In their Full Paper on page 12730 ff., E. Defrancq, B. Elias et al., report photo‐oxidant iridium(III) complexes that can target these DNA structures. As shown on this artwork, the iridium complex is able to trigger an electron transfer with guanine upon light irradiation, with the consequences to increase the prevalence of 8‐oxo‐dG.