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Frontispiece: Light‐Induced Dimerization Approaches to Control Cellular Processes
Author(s) -
Klewer Laura,
Wu YaoWen
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201985461
Subject(s) - optogenetics , transcription factor , synthetic biology , nanotechnology , chemistry , biophysics , computer science , computational biology , biology , gene , neuroscience , materials science , biochemistry
Proximity is an essential regulatory factor in biological processes , which can be controlled by induced dimerization approaches. The applications of induced proximity range from manipulation of protein folding, activation, localization, and degradation to controlling gene transcription or cell therapy. In their Review article on page 12452 ff., L. Klewer and Y.‐W. Wu explore various optogenetic systems that involve photosensitive proteins and emerging chemo‐optogenetic systems with caged or photocleavable chemical dimerizers. The advantages and disadvantages of these systems and biological applications are discussed.