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Frontispiece: Directing Traffic: Halogen‐Bond‐Mediated Membrane Transport
Author(s) -
Govindaraj Vijayakumar,
Ungati Harinarayana,
Jakka Surendar R.,
Bose Sritama,
Mugesh Govindasamy
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201984861
Subject(s) - intracellular , small molecule , membrane , membrane transport , chemistry , transporter , halogen bond , cell membrane , halogen , cell , microbiology and biotechnology , biophysics , combinatorial chemistry , nanotechnology , biochemistry , biology , materials science , organic chemistry , alkyl , gene
The efficient delivery of therapeutically active small molecules into mammalian cells is important for the development of new drugs. The transport of chemical compounds into cells is controlled by the plasma membrane, which consists of various receptors and transporters that mediate the intracellular delivery of biologically active compounds. The introduction of halogen, particularly iodine, atoms to small molecules and proteins is emerging as a novel and promising strategy not only for studying membrane activity and cellular functions, but also for improving the delivery of therapeutic agents. In their Concept article on page 11180 ff., Mugesh et. al. highlight halogen‐substitution as a novel strategy for understanding and regulating the cell‐membrane traffic.