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Frontispiece: Mirror‐Image Oligonucleotides: History and Emerging Applications
Author(s) -
Young Brian E.,
Kundu Nandini,
Sczepanski Jonathan T.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201983462
Subject(s) - oligonucleotide , computational biology , rna , biology , dna , computer science , genetics , gene
l ‐Oligonucleotides ( l ‐DNA and l ‐RNA) are enantiomers of native d ‐oligonucleotides. As such, l ‐oligonucleotides are orthogonal to the stereospecific environment of biology, making them ideal for use in biomedical applications. In this review, emerging applications of l ‐oligonucleotides are discussed, focusing on examples that illustrate how the unique properties of l ‐oligonucleotides can be exploited to obtain novel functionality, especially in biological contexts, see Minireview by J. T. Sczepanski et al. on page 7981 ff.