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Frontispiece: Biocatalytic Strategies towards [4+2] Cycloadditions
Author(s) -
Lichman Benjamin R.,
O'Connor Sarah E.,
Kries Hajo
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201982862
Subject(s) - biocatalysis , biochemical engineering , organic synthesis , chemistry , green chemistry , synthetic biology , cycloaddition , organic chemistry , combinatorial chemistry , nanotechnology , computational biology , biology , engineering , catalysis , materials science , reaction mechanism
Biocatalysis and synthetic organic chemistry play by the same physicochemical rules, but their strong suits are fundamentally different. A case in point are cycloaddition reactions: their wide use in synthetic organic chemistry contrasts with their scarcity in biological systems. In their Minireview on page 6864 ff., H. Kries et al. discuss and describe the biocatalytic strategies employed by natural [4+2] cyclases and designer enzymes created in the lab. These enzymes can potentially be developed into biocatalytic tools for organic synthesis in the future.