Premium
Frontispiece: Recent Applications of Diazirines in Chemical Proteomics
Author(s) -
Halloran Matthew W.,
Lumb JeanPhilip
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201981962
Subject(s) - diazirine , covalent bond , substrate (aquarium) , chemistry , carbene , photochemistry , nanotechnology , combinatorial chemistry , organic chemistry , materials science , catalysis , biology , ecology
UV‐light‐triggered covalent modification of a biologically activate substrate, functionalized with a diazirine, is visually represented. Upon establishing a substrate–target interaction, UV irradiation excites the diazirine to expel dinitrogen, forming a reactive carbene intermediate that can form a covalent bond to the biological target. The image portrays a ‘close‐up’ look into the cell, showing the substrate (yellow star) interacting with the biological target as well as the formation of a covalent bond after exposure to UV light. For more information, see the Minireview by M. W. Halloran and J.‐P. Lumb on page 4885 ff.