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Cover Feature: Entropy‐Driven Cooperativity in the Guest Binding of an Octaphosphonate Bis‐cavitand (Chem. Eur. J. 14/2020)
Author(s) -
Shimoyama Daisuke,
Haino Takeharu
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905859
Subject(s) - cooperativity , cavitand , cooperative binding , chemistry , entropy (arrow of time) , molecule , supramolecular chemistry , computational chemistry , crystallography , binding site , physics , thermodynamics , biochemistry , organic chemistry
An octaphosphonate biscavitand showed an uncommon entropy‐driven positive cooperativity in the guest binding. The water molecules formed the cluster‐like assemblies at the two cavities of the biscavitand in chloroform. The guest binding broke the hydrogen‐bonded water molecules, which is responsible for the entropy‐driven cooperativity in the multiple guest binding. More information can be found in the Full Paper by D. Shimoyama and T. Haino on page 3074.