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Cover Feature: Versatile Bispidine‐Based Bifunctional Chelators for 64 Cu II ‐Labelling of Biomolecules (Chem. Eur. J. 9/2020)
Author(s) -
Singh Garima,
Zarschler Kristof,
Hunoldt Sebastian,
Martínez Irma Ivette Santana,
Ruehl Carmen L.,
Matterna Madlen,
Bergmann Ralf,
Máthé Domokos,
Hegedüs Nikolett,
Bachmann Michael,
Comba Peter,
Stephan Holger
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905783
Subject(s) - bifunctional , labelling , biomolecule , chemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Bifunctional chelators for targeted nuclear imaging have been developed on the basis of bispidines. Reductive alkylation at the relatively inert C9‐position of bispidols paves the way for generating a number of derivatives ready to be coupled to a variety of targeting vector molecules. As these bispidine derivatives form highly stable complexes with the positron emitter 64 Cu II , they are virtually predestined for their application in the field of diagnostic positron emission tomography (PET). More information can be found in the Full Paper by K. Zarschler, P. Comba, H. Stephan, et al. on page 1989.