Copper‐Catalyzed Oxidative Benzylic C(sp 3 )−H Cyclization for the Synthesis of β‐Lactams | Zendy

NozawaKumada Kanako | Zendy; Saga Satoshi | Zendy; Matsuzawa Yuta | Zendy; Hayashi Masahito | Zendy; Shigeno Masanori | Zendy; Kondo Yoshinori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Copper‐Catalyzed Oxidative Benzylic C(sp 3 )−H Cyclization for the Synthesis of β‐Lactams

Author(s) -

NozawaKumada Kanako,

Saga Satoshi,

Matsuzawa Yuta,

Hayashi Masahito,

Shigeno Masanori,

Kondo Yoshinori

Publication year - 2020

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201905777

Subject(s) - intramolecular force , chemistry , catalysis , functional group , oxidative phosphorylation , combinatorial chemistry , stereochemistry , surface modification , medicinal chemistry , organic chemistry , biochemistry , polymer

β‐Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu‐catalyzed intramolecular oxidative C(sp 3 )−H amidation for the synthesis of β‐lactams using t BuOO t Bu. This method is based on Kharasch–Sosnovsky amidation and does not require prefunctionalization of C(sp 3 )−H bonds or the installation of a directing group, thereby allowing for the straightforward synthesis of β‐lactams. Our intramolecular functionalization protocol can be extended to diverse benzylic C(sp 3 )−H bonds and shows excellent functional‐group tolerance.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research