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Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I‐NBOMe
Author(s) -
Garrido Eva,
Alfonso María,
Díaz de Greñu Borja,
LozanoTorres Beatriz,
Parra Margarita,
Gaviña Pablo,
Marcos M. Dolores,
MartínezMáñez Ramón,
Sancenón Félix
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905688
Subject(s) - chemistry , rhodamine b , drug delivery , drug detection , nanodevice , materials science , nanotechnology , chromatography , organic chemistry , photocatalysis , catalysis
This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I‐NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5‐HT 2A receptor antibody. In the presence of 25I‐NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5‐HT 2A receptor antibody detachment from the surface due to its stronger coordination with 25I‐NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 μ m ) and selective recognition of the 25I‐NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I‐NBOMe illicit drug in artificial saliva and in sweets.