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Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff
Author(s) -
Yadav Prerna,
Jakubaszek Marta,
Spingler Bernhard,
Goud Bruno,
Gasser Gilles,
Zelder Felix
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905686
Subject(s) - analyte , selectivity , chemistry , pyrophosphate , fluorescence , adenosine triphosphate , combinatorial chemistry , chromatography , biochemistry , enzyme , catalysis , physics , quantum mechanics
Inorganic pyrophosphate (PPi) is considered as a diagnostic marker for various diseases such as cancer and vascular calcification. PPi also plays an important preservative role as an additive E450 in foodstuff. In this work, a selective Fe III –salen‐based probe for PPi is described; this probe disassembles in the presence of the target analyte into its molecular blocks, 1,2‐propanediamine and 3‐chloro‐5‐formyl‐4‐hydroxybenzenesulfonic acid. The latter signaling unit leads to a fluorometric response. Compared with a related prototype, the new complex shows a 2.3‐times stronger emission at 500 nm and a 155‐times better selectivity of PPi over adenosine triphosphate (ATP). Importantly, the new probe was successfully applied for detecting E450 in foodstuff.