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Cover Feature: A Mild and Versatile Friedel–Crafts Methodology for the Diversity‐Oriented Synthesis of Redox‐Active 3‐Benzoylmenadiones with Tunable Redox Potentials (Chem. Eur. J. 15/2020)
Author(s) -
Cotos Leandro,
Donzel Maxime,
Elhabiri Mourad,
DavioudCharvet Elisabeth
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905613
Subject(s) - redox , friedel–crafts reaction , combinatorial chemistry , acylation , benzoic acid , chemistry , cover (algebra) , organic chemistry , catalysis , mechanical engineering , engineering
A new Friedel‐Crafts acylation variant was achieved from various activated/deactivated benzoic and heteroaromatic carboxylic acids under mild and versatile conditions to produce highly diversified 3‐aroylmenadiones. The reached structural diversity in the key metabolites of the lead antimalarial agents allowed to subtly modulate E 2 1/2 redox potentials, which is a crucial step in any redox‐active drug discovery program. More information can be found in the Full Paper by M. Elhabiri, E. Davioud‐Charvet et al. on page 3314.