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Front Cover: A Quadrupolar Bis‐Triarylborane Chromophore as a Fluorimetric and Chirooptic Probe for Simultaneous and Selective Sensing of DNA, RNA and Proteins (Chem. Eur. J. 10/2020)
Author(s) -
Ban Željka,
Griesbeck Stefanie,
Tomić Sanja,
Nitsch Jörn,
Marder Todd B.,
Piantanida Ivo
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905567
Subject(s) - dna , chromophore , fluorescence , rna , front cover , cover (algebra) , microbiology and biotechnology , chemistry , biophysics , in vitro , biology , biochemistry , physics , gene , photochemistry , optics , mechanical engineering , engineering
One dye to detect them all : A tetracationic quadrupolar bis‐triarylborane dye can bind with 10–100 nM affinity and efficiently distinguish between DNA/RNA and BSA by characteristic fluorescence emission points separated by Δ ν ˜ =3600 cm −1 , allowing the simultaneous quantification of DNA/RNA and protein (BSA) in a mixture. The applicability of such fluorimetric differentiation in vitro was demonstrated, strongly supporting a protein‐like target as a dominant binding site of this dye in human cells. More information can be found in the Full Paper by T. B. Marder, I. Piantanida, et al. on page 2195.