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Ruthenium‐Induced Cyclization of Heteroatom‐Functionalized Alkynes: Progress, Challenges and Perspectives
Author(s) -
Chung LaiHon,
Yeung ChiFung,
Wong ChunYuen
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905506
Subject(s) - alkyne , heteroatom , electrophile , ruthenium , chemistry , combinatorial chemistry , organic chemistry , catalysis , ring (chemistry)
Metal‐induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although Ru II centers are well‐established to promote alkyne to vinylidene rearrangements and many Ru II ‐mediated alkyne cyclizations have been rationalized to be the results of post‐vinylidene transformations, recent discoveries indicate that Ru II centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In this Minireview, an overview of the Ru II ‐induced cyclization of heteroatom‐functionalized alkynes in the last decade is provided, with an emphasis on the discoveries and validations of the unconventional “non‐vinylidene‐involving” pathways.