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Diverse Approaches for Enantioselective C−H Functionalization Reactions Using Group 9 Cp x M III Catalysts
Author(s) -
Yoshino Tatsuhiko,
Satake Shun,
Matsunaga Shigeki
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905417
Subject(s) - enantioselective synthesis , catalysis , chemistry , surface modification , combinatorial chemistry , carboxylate , ligand (biochemistry) , chiral ligand , stereochemistry , organic chemistry , biochemistry , receptor
Transition‐metal‐catalyzed C−H functionalization reactions with Cp*M III catalysts (M=Co, Rh, Ir) have found a wide variety of applications in organic synthesis. Albeit the intrinsic difficulties in achieving catalytic stereocontrol using these catalysts due to their lack of additional coordination sites for external chiral ligands and the conformational flexibility of the Cp ligand, catalytic enantioselective C−H functionalization reactions using the Group 9 metal triad with Cp‐type ligands have been intensively studied since 2012. In this minireview, the progress in these reactions according to the type of the chiral catalyst used are summarized and discussed. The development of chiral Cp x ligands the metal complexes thereof, artificial metalloenzymes, chiral carboxylate‐assisted enantioselective C−H activations, enantioselective alkylations assisted by chiral carboxylic acids or chiral sulfonates, and chiral transient directing groups are discussed.