Premium
Galactose‐Grafted 2D Nanosheets from the Self‐Assembly of Amphiphilic Janus Dendrimers for the Capture and Agglutination of Escherichia coli
Author(s) -
Krishnan Nithiyanandan,
Perumal Devanathan,
Atchimnaidu Siriki,
Harikrishnan Kaloor S.,
Golla Murali,
Kumar Nilima Manoj,
Kalathil Jemshiya,
Krishna Jithu,
Vijayan Dileep K.,
Varghese Reji
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905228
Subject(s) - janus , amphiphile , nanotechnology , dendrimer , supramolecular chemistry , self assembly , materials science , biomolecule , escherichia coli , chemistry , biophysics , molecule , biochemistry , biology , organic chemistry , polymer , copolymer , gene
High aspect ratio, sugar‐decorated 2D nanosheets are ideal candidates for the capture and agglutination of bacteria. Herein, the design and synthesis of two carbohydrate‐based Janus amphiphiles that spontaneously self‐assemble into high aspect ratio 2D sheets are reported. The unique structural features of the sheets include the extremely high aspect ratio and dense display of galactose on the surface. These structural characteristics allow the sheet to act as a supramolecular 2D platform for the capture and agglutination of E. coli through specific multivalent noncovalent interactions, which significantly reduces the mobility of the bacteria and leads to the inhibition of their proliferation. Our results suggest that the design strategy demonstrated here can be applied as a general approach for the crafting of biomolecule‐decorated 2D nanosheets, which can perform as 2D platforms for their interaction with specific targets.