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In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for the Development of Enantioselective C−O Bond Arylation
Author(s) -
Kondo Hikaru,
Kochi Takuya,
Kakiuchi Fumitoshi
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201905157
Subject(s) - phosphine , enantioselective synthesis , ruthenium , in situ , chemistry , denticity , catalysis , styrene , cleavage (geology) , ligand (biochemistry) , bond cleavage , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , copolymer , metal , polymer , biochemistry , receptor , fracture (geology) , composite material
We report here a method for in situ generation of various ruthenium carbonyl phosphine catalysts for arylation via cleavage of inert aromatic carbon–oxygen bonds. The use of catalyst systems consisting of [RuCl 2 (CO)( p ‐cymene)], CsF, styrene, and phosphines enabled facile screening of phosphine ligands. Asymmetric C–O arylation was also achieved for atropo‐enantioselective biaryl synthesis using a chiral monodentate phosphine ligand.