In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for the Development of Enantioselective C−O Bond Arylation | Zendy

Kondo Hikaru | Zendy; Kochi Takuya | Zendy; Kakiuchi Fumitoshi | Zendy

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In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for the Development of Enantioselective C−O Bond Arylation

Author(s) -

Kondo Hikaru,

Kochi Takuya,

Kakiuchi Fumitoshi

Publication year - 2020

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201905157

Subject(s) - phosphine , enantioselective synthesis , ruthenium , in situ , chemistry , denticity , catalysis , styrene , cleavage (geology) , ligand (biochemistry) , bond cleavage , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , copolymer , metal , polymer , biochemistry , receptor , fracture (geology) , composite material

We report here a method for in situ generation of various ruthenium carbonyl phosphine catalysts for arylation via cleavage of inert aromatic carbon–oxygen bonds. The use of catalyst systems consisting of [RuCl 2 (CO)( p ‐cymene)], CsF, styrene, and phosphines enabled facile screening of phosphine ligands. Asymmetric C–O arylation was also achieved for atropo‐enantioselective biaryl synthesis using a chiral monodentate phosphine ligand.

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