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Total Syntheses of 11‐Acetoxy‐4‐deoxyasbestinin D, 4‐Deoxyasbestinin C, Asbestinin‐10, ‐20, ‐21 and ‐23
Author(s) -
Campbell Angus,
Som Ian Mat,
Wilson Claire,
Clark J. Stephen
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904998
Subject(s) - diterpene , natural product , diastereomer , stereochemistry , stereoselectivity , total synthesis , chemistry , organic chemistry , catalysis
Six members of the asbestinin family of marine diterpene natural products have been synthesized in an efficient and stereoselective manner from a single oxa‐bridged intermediate. Five of these natural products have not been synthesized previously and the structures of four of them have been confirmed as those proposed originally or following revisions to the original structures. The fifth natural product—asbestinin‐21—has been shown to be a diastereomer of the compound that had been proposed previously.