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Cover Feature: Reductant‐Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins (Chem. Eur. J. 69/2019)
Author(s) -
Rahimidashaghoul Kheironnesae,
Klimánková Iveta,
Hubálek Martin,
Korecký Michal,
Chvojka Matúš,
Pokorný Daniel,
Matoušek Václav,
Fojtík Lukáš,
Kavan Daniel,
Kukačka Zdeněk,
Novák Petr,
Beier Petr
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904806
Subject(s) - hypervalent molecule , reagent , chemistry , tryptophan , iodine , combinatorial chemistry , amino acid , methionine , conjugate , nitrogen , organic chemistry , biochemistry , mathematical analysis , mathematics
In an underwater sea scene , the key process of protein functionalization on tryptophan is shown. The follow‐up click reaction by using the pink reagent carrying a payload delivers the conjugate of choice. Realistic depiction of hypervalent iodine reagents includes the T‐shape geometry on the iodine atom and the azido‐containing fluoroalkyl group. On the seabed there are side products from the reagent after the reaction with the protein. More information can be found in the Full Paper by P. Novák, P. Beier, et al. on page 15779.