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Photoinduced Processes within Noncovalent Complexes Involved in Molecular Recognition
Author(s) -
Abdelmouleh Marwa,
Lalande Mathieu,
Vizcaino Violaine,
Schlathölter Thomas,
Poully JeanChristophe
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904786
Subject(s) - chemistry , non covalent interactions , glycosidic bond , protonation , ligand (biochemistry) , molecular recognition , deprotonation , stereochemistry , photochemistry , biophysics , receptor , molecule , hydrogen bond , biochemistry , organic chemistry , ion , enzyme , biology
Investigating the intrinsic properties of molecular complexes is crucial for understanding the influence of noncovalent interactions on fundamental chemical reactions. Moreover, specific molecular recognition between a ligand and its receptor is a highly important biological process, but little is known about the effects of ionizing radiation on ligand–receptor complexes. The processes triggered by VUV photoabsorption on isolated noncovalent complexes between the glycopeptide antibiotic vancomycin and a mimic of its receptor have been probed by means of mass spectrometry and synchrotron radiation. In the case of protonated species, the glycosidic bond of vancomycin was cleaved with low activation energy, regardless of the molecular environment. In sharp contrast, for deprotonated species, electron photodetachment from carboxylate groups only triggered CO 2 loss, whereas the glycosidic bond remained intact. Importantly, the noncovalent complex was also found to survive VUV photoabsorption only when the native structure is conserved in the gas phase.