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Cover Feature: Selenosulfides Tethered to gem ‐Dimethyl Esters: A Robust and Highly Versatile Framework for H 2 S Probe Development (Chem. Eur. J. 69/2019)
Author(s) -
Suarez S. Israel,
Ambrose Rynne,
Kalk Madison A.,
Lukesh John C.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904784
Subject(s) - selectivity , hydrogen sulfide , chemistry , flexibility (engineering) , cover (algebra) , molecule , combinatorial chemistry , computer science , nanotechnology , materials science , organic chemistry , engineering , mechanical engineering , mathematics , sulfur , statistics , catalysis
To broaden our understanding of hydrogen sulfide (H 2 S) as an endogenous signaling molecule, new chemical tools are needed to further probe its biological significance. A new reaction‐based scaffold for the selective detection and imaging of H 2 S within live cells was developed. The reported probes display excellent selectivity and sensitivity towards H 2 S and with improved structural flexibility such that issues related to poor water solubility, cell permeability, or tissue specificity may be easily addressed. More information can be found in the Communication by J. C. Lukesh III et al. on page 15736.