Premium
Cover Feature: Functionalized Resins for the Synthesis of Peptide Alcohols (Chem. Eur. J. 2/2020)
Author(s) -
FerrerGago Fernando J.,
Koh Li Quan,
Lane David P.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904783
Subject(s) - linker , polystyrene , polyethylene glycol , peg ratio , peptide , chemistry , cover (algebra) , combinatorial chemistry , polymer chemistry , polymer , organic chemistry , computer science , biochemistry , mechanical engineering , engineering , finance , economics , operating system
The resin's beads (in the column) are a polymer, such as polystyrene (PS) or polyethylene glycol (PEG), that can be functionalized with several linkers (e.g., the phenylalaninol‐Rink linker) to render beads that are ready for the synthesis of peptide alcohols. As an example, the functionalized resins can produce stapled peptide alcohols with a phenylalaninol at the C terminus. More information can be found in the Communication by F. J. Ferrer‐Gago et al. on page 379.