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Photoinduced Decarboxylative Amino‐Fluoroalkylation of Maleic Anhydride
Author(s) -
Sun Youwen,
Zhang Guozhu
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904751
Subject(s) - maleic anhydride , amine gas treating , alkyl , chemistry , decarboxylation , selectivity , organic chemistry , polymer , catalysis , copolymer
A photoinduced decarboxylative three‐component coupling reaction involving amine, maleic anhydride, and fluorinated alkyl iodides has been developed, leading to synthetically valuable fluoroalkyl‐containing acrylamides with a high E selectivity. A broad array of substrates including monoprotected amino acid are capable coupling partners. Preliminary mechanistic studies suggest a stepwise process. This reaction represents the first example of photoinduced decarboxylative difunctionalization of maleic anhydride.