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A Ru II Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy
Author(s) -
Hu Xiaochun,
Lu Yonglin,
Dong Chunyan,
Zhao Wenrong,
Wu Xuewen,
Zhou Lulu,
Chen Lv,
Yao Tianming,
Shi Shuo
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904704
Subject(s) - photothermal therapy , photodynamic therapy , photosensitizer , drug delivery , alkyne , nanotechnology , photothermal effect , materials science , nanoparticle , chemistry , combinatorial chemistry , photochemistry , catalysis , organic chemistry
Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO‐66‐N 3 ) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A Ru II polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as‐prepared multifunctional nanoplatform (UiO‐Ra‐DOX‐CuS) not only demonstrated efficient 1 O 2 generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual‐stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO‐Ra‐DOX‐CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of Ru II polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment.