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Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
Author(s) -
Frei Angelo,
Amado Maite,
Cooper Matthew A.,
Blaskovich Mark A. T.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904689
Subject(s) - mode of action , bacteria , drug , rhenium , antibiotics , chemistry , antibacterial activity , mechanism of action , drug discovery , mutant , microbiology and biotechnology , dual mode , combinatorial chemistry , pharmacology , biology , biochemistry , in vitro , genetics , organic chemistry , engineering , gene , aerospace engineering
New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli . The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.