Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria | Zendy

Frei Angelo | Zendy; Amado Maite | Zendy; Cooper Matthew A. | Zendy; Blaskovich Mark A. T. | Zendy

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Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria

Author(s) -

Frei Angelo,

Amado Maite,

Cooper Matthew A.,

Blaskovich Mark A. T.

Publication year - 2020

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201904689

Subject(s) - rhenium , dual (grammatical number) , bacteria , dual mode , action (physics) , mode of action , chemistry , biology , biochemistry , art , inorganic chemistry , physics , genetics , engineering , aerospace engineering , literature , quantum mechanics

New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli . The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

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