Premium
Front Cover: Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells (Chem. Eur. J. 68/2019)
Author(s) -
Liet Benjamin,
Laigre Eugénie,
Goyard David,
Todaro Biagio,
Tiertant Claire,
Boturyn Didier,
Berthet Nathalie,
Renaudet Olivier
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904615
Subject(s) - front cover , antibody , glycoconjugate , chemistry , cytotoxic t cell , cancer , in vivo , immune system , cancer immunotherapy , cancer cell , immunization , immunotherapy , cancer research , biology , in vitro , immunology , biochemistry , cover (algebra) , genetics , engineering , mechanical engineering
The utility of synthetic chemistry in cancer immunotherapy has been demonstrated over the past decades with antitumoral vaccines and antibody recruiting molecules (ARM). By using click chemistry, polyfunctional ARMs composed of multivalent antibody and tumoral binding modules to guide natural antibodies to cancer cells without pre‐immunization step have been developed. The resulting ARM was found to promote the formation of a ternary complex that is required for the stimulation of cytotoxic immune response in vivo. More information can be found in the Full Paper by N. Berthet, O. Renaudet, et al. on page 15508.