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Front Cover: Oxidation of Enones for Regioselective [3+2] Cycloaddition through γ‐Enone Radical Intermediates (Chem. Eur. J. 67/2019)
Author(s) -
Kan Jian,
Zhang Min,
Zhang Xiaofeng,
Lou Xin,
Shang Yaping,
Xu Biping,
Yang Fanyuanhang,
Su Weiping
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904611
Subject(s) - enone , cycloaddition , regioselectivity , ketone , chemistry , front cover , reactivity (psychology) , double bond , photochemistry , cover (algebra) , medicinal chemistry , organic chemistry , catalysis , mechanical engineering , engineering , medicine , alternative medicine , pathology
The oxidation of enones with a Cu II complex regioselectively afforded [3+2] cycloaddition products, namely, highly functionalized cyclopentenes and spirocyclic compounds. This reaction occurs through an initial formation of a γ‐enone radical intermediate, and subsequent [3+2] cycloaddition of the γ‐enone radical to the β,γ‐unsaturated ketone derived from enone double‐bond migration, exhibiting a rarely explored reactivity pattern for enones. More information can be found in the Communication by M. Zhang, W. Su et al. on page 15233.