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Cover Feature: Computer‐Assisted Recombination (CompassR) Teaches us How to Recombine Beneficial Substitutions from Directed Evolution Campaigns (Chem. Eur. J. 3/2020)
Author(s) -
Cui Haiyang,
Cao Hao,
Cai Haiying,
Jaeger KarlErich,
Davari Mehdi D.,
Schwaneberg Ulrich
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904578
Subject(s) - recombination , cover (algebra) , selection (genetic algorithm) , folding (dsp implementation) , computer science , pathfinder , computational biology , genetics , physics , biology , gene , artificial intelligence , engineering , world wide web , mechanical engineering , electrical engineering
The Computer‐assisted Recombination (CompassR) strategy is a selection filter for experimentalists to recombine beneficial substitutions in order to gradually improve enzyme performance and maximize improvements through recombination. CompassR works through the analysis of the relative free energy of folding (ΔΔ G fold ) and essentially acts as a recombination pathfinder app for recombining beneficial substitutions that have been identified by directed evolution and/or computational design. More information can be found in the Full Paper by U. Schwaneberg et al. on page 643.