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A Comparative Synthetic Strategy Perspective on α‐Amino Acid‐ and Non‐Amino Acid‐Derived Synthons towards Total Syntheses of Selected Natural Macrolides
Author(s) -
Kumar Manda Srinivas Lavanya,
Tripathi Shashank,
Ghoshal Anirban,
Ambule Mayur D.,
Srivastava Ajay Kumar,
Panda Gautam
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904564
Subject(s) - synthon , amino acid , chemistry , total synthesis , combinatorial chemistry , stereochemistry , drug discovery , biological activity , computational biology , biochemistry , biology , in vitro
Macrocyclic alkaloids (macrolides) and cyclopeptides have an immense range of applications in drug discovery research because of their natural abundance and potential biological and physicochemical properties. Presently, more than 100 approved drugs or clinical drug candidates contain macrocyclic scaffolds as the biologically active component. This review provides an interesting perspective about the use of amino acid‐derived chiral pools versus other methods derived from miscellaneous synthons towards the total synthesis of non‐peptidic macrolides. The synthetic routes and the key strategies involved in the total syntheses of ten natural macrolides have been discussed. Both the amino acid‐derived and non‐amino acid‐derived synthetic routes have been illustrated to present a comparative study between the two approaches.