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Strategies for Tumor Hypoxia Imaging Based on Aggregation‐Induced Emission Fluorogens
Author(s) -
Xue Tianhao,
Shen Jiajia,
Shao Kuanchun,
Wang Wei,
Wu Bing,
He Yaning
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904327
Subject(s) - photobleaching , aggregation induced emission , hypoxia (environmental) , fluorescence , brightness , chemistry , nanotechnology , biophysics , materials science , biology , oxygen , optics , physics , organic chemistry
Hypoxia, as a crucial characteristic of cancer, has become an extremely significant direction for researchers to construct fluorescent probes for early diagnosis of tumors. Aggregation‐induced emission fluorogens (AIEgens) possess many superior properties to those of conventional fluorophores due to aggregation‐induced emission (AIE) features, such as a linear concentration‐dependent increase in brightness, remarkable resistance to photobleaching, and the long‐term tracking and imaging of cells. Constructing hypoxic response AIEgen‐based probes will be very useful for the early diagnosis of tumors. Herein, several hypoxia‐responsive probes based on AIEgens reported in the last three years are reported; these examples may lead to the construction of hypoxia‐responsive AIE probes used for tumor hypoxia imaging in the future. In addition, typical, conventional hypoxia‐responsive bioprobes are presented to further understand hypoxia‐responsive fluorescent probes based on AIEgens.