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Cover Feature: Mechanism of Oxidative Activation of Fluorinated Aromatic Compounds by N‐Bridged Diiron‐Phthalocyanine: What Determines the Reactivity? (Chem. Eur. J. 63/2019)
Author(s) -
Colomban Cédric,
Tobing Anthonio H.,
Mukherjee Gourab,
Sastri Chivukula V.,
Sorokin Alexander B.,
Visser Sam P.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904315
Subject(s) - hydroxylation , chemistry , reactivity (psychology) , aromaticity , oxidative phosphorylation , ketone , enzyme , mechanism (biology) , stereochemistry , medicinal chemistry , organic chemistry , molecule , biochemistry , medicine , philosophy , alternative medicine , epistemology , pathology
A high‐valent diiron‐oxo species that can react with perfluoroarenes through an oxidative pathway is described. As far as the authors are aware, no enzymatic iron enzymes are able to complete this feat. Furthermore, it is shown that the aromatic hydroxylation of perfluoroarenes involves the activation of strong C−F bonds and operates through a different mechanism than that of arenes. The authors demonstrated a mechanism of defluorination via a ketone intermediate, which is a side‐product for aromatic hydroxylation. More information can be found in the Full Paper by A. B. Sorokin, S. P. de Visser, et al. on page 14320.