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Dual Responsive Regulation of Host–Guest Complexation in Aqueous Media to Control Partial Release of the Host
Author(s) -
Guo Hui,
Hourdet Dominique,
Marcellan Alba,
Stoffelbach François,
Lyskawa Joel,
Smet Lieselot,
Vebr Aurélien,
Hoogenboom Richard,
Woisel Patrice
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904287
Subject(s) - chemistry , monomer , supramolecular chemistry , copolymer , aqueous solution , molecule , aqueous medium , acrylic acid , dual (grammatical number) , host (biology) , combinatorial chemistry , nanotechnology , chemical engineering , polymer chemistry , polymer , organic chemistry , materials science , art , literature , ecology , engineering , biology
Abstract The regulation of the concentration of a wide range of small molecules is ubiquitous in biological systems because it enables them to adapt to the continuous changes in the environmental conditions. Herein, we report an aqueous synthetic system that provides an orchestrated, temperature and pH controlled regulation of the complexation between the cyclobis(paraquat‐ p ‐phenylene) host ( BBox ) and a 1,5‐dialkyloxynaphthalene ( DNP ) guest attached to a well‐defined dual responsive copolymer composed of N ‐isopropylacrylamide as thermoresponsive monomer and acrylic acid as pH‐responsive monomer. Controlled, partial release of the BBox , enabling control over its concentration, is based on the tunable partial collapse of the copolymer. This colored supramolecular assembly is one of the first synthetic systems providing control over the concentration of a small molecule, providing great potential as both T and pH chromic materials and as a basis to develop more complex systems with molecular communication.