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Retracted: Synthesis of 2‐Arylisoindoline Derivatives Catalyzed by Reusable 1,2,4‐Triazole Iridium on Mesoporous Silica through a Cascade Borrowing Hydrogen Strategy
Author(s) -
Yao Wei,
Ge Chenyang,
Zhang Yilin,
Xia XiaoFeng,
Wang Long,
Wang Dawei
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904095
Subject(s) - iridium , catalysis , isoindoline , aryl , chemistry , combinatorial chemistry , mesoporous material , dehydrogenation , mesoporous silica , hydride , hydrogen , organic chemistry , alkyl
Covalent attachment of a 1,2,4‐triazole iridium complex to mesoporous MCM‐41 generated a heterogeneous catalyst that was found to be effective in the synthesis of 2‐aryl isoindolines, quinolines, cyclic amines, and symmetrical secondary amines through a cascade borrowing hydrogen strategy. Interestingly, the supported heterogeneous iridium catalyst prepared from the 1,2,4‐triazole iridium complex and mesoporous MCM‐41 exhibited high catalytic activity in the preparation of 2‐aryl isoindoline derivatives and symmetrical secondary amines. The catalyst system is highly recyclable for at least five times. Besides the important effect of the triazole, iridium sites grafted on siliceous supports can act as multifunctional catalytic centers and thus greatly enhance the catalytic activity of the catalysts. Furthermore, mechanistic experiments revealed that the reaction is initiated by an initial alcohol dehydrogenation and promoted by an iridium hydride intermediate. Importantly, the direct detection of a diagnostic iridium hydride signal confirmed that the synthesis of 2‐aryl isoindolines occurs by a borrowing hydrogen process. This work provides an efficient example of isoindolines synthesis through a borrowing hydrogen strategy.