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The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics
Author(s) -
Pidot Sacha J.,
Rizzacasa Mark A.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904053
Subject(s) - antimicrobial , broad spectrum , moiety , antibiotics , antibiotic resistance , biology , stereochemistry , combinatorial chemistry , genetics , chemistry , microbiology and biotechnology
The nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis ‐decalin moiety and a narrow spectrum of activity. Most family members were identified almost four decades ago and were placed on the shelf due to the numbers of broad‐spectrum compounds available at the time. However, in light of rising rates of antimicrobial resistance, there has been a renewed interest in the use of narrow‐spectrum antimicrobials. Here, we review the history of this family of compounds, including synthetic approaches, and highlight the recently uncovered genetic basis for nargenicin production. Given the renewed pharmaceutical interest in these compounds, we also investigate structure–activity relationships among these molecules, with a view to the future development of members of this unusual antibiotic family.