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Front Cover: Deracemization in a Complex Quaternary System with a Second‐Order Asymmetric Transformation by Using Phase Diagram Studies (Chem. Eur. J. 61/2019)
Author(s) -
Oketani Ryusei,
Marin Francesco,
Tinnemans Paul,
Hoquante Marine,
Laurent Anne,
Brandel Clément,
Cardinael Pascal,
Meekes Hugo,
Vlieg Elias,
Geerts Yves,
Coquerel Gérard
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904003
Subject(s) - racemization , phase diagram , quaternary , phase (matter) , transformation (genetics) , crystallization , computer science , materials science , thermodynamics , mathematics , biological system , chemistry , physics , stereochemistry , organic chemistry , geology , biology , paleontology , biochemistry , gene
Phase diagrams play a critical role for tuning crystallization. This study explains the basics of phase diagrams starting from the ternary system to a quaternary system with and without fast racemization in the liquid phase. Experimentally, an atropisomeric naphthamide derivative in MeOH/H 2 O serves as an example. Deracemization is ensured by a second‐order asymmetric transformation up to 97% ee . Readers are encouraged to look at the animation (in the Supporting Information) detailing the construction of the degenerated quaternary system in a step‐by‐step manner. More information can be found in the Full Paper by G. Coquerel et al. on page 13890.