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Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged Ru II Complexes
Author(s) -
Feng Yang,
Sun WeiZe,
Wang XueSong,
Zhou QianXiong
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903923
Subject(s) - staphylococcus aureus , phototoxicity , hemolysis , antimicrobial , ruthenium , microbiology and biotechnology , chemistry , photodynamic therapy , ammonium , ruthenium red , bacteria , biology , biochemistry , immunology , in vitro , calcium , genetics , organic chemistry , catalysis
Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus ( S. aureus ), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents.