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Front Cover: KRAS Binders Hidden in Nature (Chem. Eur. J. 52/2019)
Author(s) -
Bergner Andreas,
Cockcroft Xiaoling,
Fischer Gerhard,
Gollner Andreas,
Hela Wolfgang,
Kousek Roland,
Mantoulidis Andreas,
Martin Laetitia J.,
Mayer Moriz,
Müllauer Barbara,
Siszler Gabriella,
Wolkerstorfer Bernhard,
Kessler Dirk,
McConnell Darryl B.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903597
Subject(s) - kras , drug discovery , key (lock) , lock (firearm) , front cover , computational biology , computer science , front (military) , cover (algebra) , ideal (ethics) , chemistry , biology , bioinformatics , physics , engineering , mutation , biochemistry , gene , philosophy , computer security , mechanical engineering , meteorology , epistemology
Drug discovery is in essence the discovery of a molecular key (the drug) which fits into a lock (scientists call them pockets) on a disease‐causing protein. The lock on KRAS is extremely small, making it almost impossible for chemists to find a key to fit tightly enough into it. Nature has solved this problem by making highly rigid chemical scaffolds (rigid keys) that are capable of binding tightly to such shallow pockets. This work reports the discovery of rigid keys from nature that bind to KRAS and are ideal starting points for the discovery of future KRAS cancer drugs. More information can be found in the Communication by D. B. McConnell et al. on page 12037.