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“Dark” Singlet Oxygen Made Easy
Author(s) -
Elsherbini Mohamed,
Allemann Rudolf K.,
Wirth Thomas
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903505
Subject(s) - singlet oxygen , artemisinin , oxygen , singlet state , generator (circuit theory) , photochemistry , chemistry , simple (philosophy) , continuous flow , combinatorial chemistry , materials science , organic chemistry , physics , power (physics) , atomic physics , malaria , thermodynamics , mechanics , immunology , plasmodium falciparum , biology , excited state , philosophy , epistemology
An operationally simple continuous flow generator of “dark” singlet oxygen has been developed. The singlet oxygen was efficiently reacted with several chemical traps to give the corresponding oxygenated products in high yields. The developed “dark” singlet oxygen generator has been successfully applied in the synthesis of the antimalarial drug artemisinin.