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Cationic Chalcogenoviologen Derivatives for Photodynamic Antimicrobial Therapy and Skin Regeneration
Author(s) -
Zhou Kun,
Tian Ran,
Li Guoping,
Qiu Xinyu,
Xu Letian,
Guo Mengying,
Chigan Dongdong,
Zhang Yanfeng,
Chen Xin,
He Gang
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903278
Subject(s) - antimicrobial , cationic polymerization , photodynamic therapy , chemistry , photosensitizer , reactive oxygen species , regeneration (biology) , alkyl , combinatorial chemistry , ammonium , organic chemistry , biochemistry , biology , microbiology and biotechnology
A series of water‐soluble cationic chalcogenoviologen‐based photosensitizers for photodynamic antimicrobial therapy (PDAT) is reported. The Se‐containing derivatives (SeMV 2+ ) 5 b and 6 b showed good antimicrobial activities due to the presence of chalcogen atoms and a cationic scaffold. The former efficiently enhanced the generation of reactive oxygen species (ROS), and the latter facilitated the ROS delivery to bacteria, resulting in their death. Interestingly, alkyl‐modified photosensitizers showed higher antimicrobial activities than commonly reported photosensitizers with quaternary ammonium (QA) groups. In particular, the SeMV 2+ ( 6 b ) with excellent antibacterial activities efficiently promoted the healing of infected wounds in mice. Simple yet novel, nontoxic and biocompatible chalcogenoviologens provided a promising strategy to develop new efficient photosensitizers for photodynamic antimicrobial therapy and skin regeneration.