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The Symbiotic Relationship Between Drug Discovery and Organic Chemistry
Author(s) -
Grygorenko Oleksandr O.,
Volochnyuk Dmitriy M.,
Ryabukhin Sergey V.,
Judd Duncan B.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903232
Subject(s) - chemical space , drug discovery , natural product , organic synthesis , chemistry , organic molecules , combinatorial chemistry , biochemical engineering , nanotechnology , computer science , data science , engineering , organic chemistry , molecule , materials science , biochemistry , catalysis
All pharmaceutical products contain organic molecules; the source may be a natural product or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry underpins both existing and upcoming pharmaceutical products. The reverse relationship has also affected organic synthesis, changing its landscape towards increasingly complex targets. This Review article sets out to give a concise appraisal of this symbiotic relationship between organic chemistry and drug discovery, along with a discussion of the design concepts and highlighting key milestones along the journey. In particular, criteria for a high‐quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry; diversity‐, biology‐, lead‐, or fragment‐oriented syntheses; and DNA‐encoded libraries) are critically surveyed.