Premium
Cover Feature: Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH⋅⋅⋅Se Hydrogen Bond through Stabilization of the Mixed Se−S Intermediate (Chem. Eur. J. 55/2019)
Author(s) -
Arai Kenta,
Matsunaga Takahiko,
Ueno Haruhito,
Akahoshi Nozomi,
Sato Yuumi,
Chakrabarty Gaurango,
Mugesh Govindasamy,
Iwaoka Michio
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201903073
Subject(s) - thioredoxin reductase , chemistry , thioredoxin , cover (algebra) , hydrogen bond , reductase , catalysis , enzyme , biochemistry , organic chemistry , molecule , engineering , mechanical engineering
A model study using synthetic selenenyl sulfides revealed that the basic His472 would accelerate the reduction of the Se−S bond in the catalytic cycle of thioredoxin reductase (TrxR). More information can be found in the Full Paper by G. Mugesh, M. Iwaoka, et al. on page 12751.