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Fmoc‐Dipeptide/Porphyrin Molar Ratio Dictates Energy Transfer Efficiency in Nanostructures Produced by Biocatalytic Co‐Assembly
Author(s) -
Wijerathne Nadeesha K.,
Kumar Mohit,
Ulijn Rein V.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902819
Subject(s) - porphyrin , self assembly , dipeptide , nanostructure , nanofiber , aqueous solution , amphiphile , chemistry , copolymer , chemical engineering , materials science , nanotechnology , peptide , combinatorial chemistry , photochemistry , organic chemistry , polymer , biochemistry , engineering
Abstract The controlled self‐assembly of porphyrin derivatives (TCPP, tetrakis(4‐carboxyphenyl)porphyrin) within Fmoc‐protected (Fmoc=9‐Fluorenylmethyloxycarbonyl) dipeptide (Fmoc‐TL‐NH 2 ) nanofibers is demonstrated. The biocatalytic co‐assembly in aqueous medium generated an energy transfer hydrogel. Depending on the concentrations of porphyrin used, the resulting nanofibrous gels show two distinct regions of self‐assembly behavior that is, integration of TCPP into nanostructures to produce two‐component co‐assembly fibers, or heterogeneous self‐aggregation of TCPP within the self‐assembled matrix observed at higher concentrations. The mode of assembly directly impacts on the energy transfer efficiency of these nanostructures. These results show that reversible biocatalytic co‐assembly of structural and functional components enables fine‐tuning of peptide/porphyrin energy transfer nanostructures.