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Glycopeptides by Linch‐Pin C−H Activations for Peptide‐Carbohydrate Conjugation by Manganese(I)‐Catalysis
Author(s) -
Wang Wei,
Subramanian Parthasarathi,
Martinazzoli Oscar,
Wu Jun,
Ackermann Lutz
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902788
Subject(s) - glycopeptide , chemistry , catalysis , manganese , peptide , carbohydrate , combinatorial chemistry , biochemistry , organic chemistry , antibiotics
Late‐stage C−H glycosylations of structurally complex amino acids and peptides were accomplished by means of racemization‐free manganese(I)‐catalyzed C−H activation. Thus, glycosylative modifications proved to be viable by a linch‐pin approach, featuring chemo‐ and site‐selective C−H transformations. The peptide–saccharide conjugation provided modular access to structurally complex glycopeptides, likewise enabling the assembly of fluorescent‐labelled glycopeptides.