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Polyoxygenated Tertiary Alcohols: A Kiyooka Approach
Author(s) -
Lücke Daniel,
Kalesse Markus
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902589
Subject(s) - ketene , tertiary alcohols , acetal , stereoselectivity , alcohol , aldol reaction , center (category theory) , chemistry , tertiary care , organic chemistry , stereochemistry , catalysis , crystallography , medicine , family medicine
A Kiyooka aldol approach for the stereoselective synthesis of tertiary alcohols is presented. This approach allows for the incorporation of different substituents at all three remaining positions at the chiral center bearing the tertiary alcohol. To demonstrate the validity of this approach different chiral alcohols were depicted and the relationship of double bond geometry of the ketene acetal and the diastereoselectivity was established.