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Cover Feature: New Size‐Expanded Fluorescent Thymine Analogue: Synthesis, Characterization, and Application (Chem. Eur. J. 42/2019)
Author(s) -
Hirashima Shingo,
Han Ji Hoon,
Tsuno Hitomi,
Tanigaki Yusuke,
Park Soyoung,
Sugiyama Hiroshi
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902547
Subject(s) - fluorescence , thymine , duplex (building) , quantum yield , chemistry , biophysics , dna , biology , biochemistry , physics , optics
A new size‐expanded fluorescent T‐mimic deoxyribonucleoside is reported, based on a dioxoloquinazoline core, named as diox T . diox T showed comparable biophysical properties and displayed notable photophysical characteristics including an excellent quantum yield (0.36) in water as a fluorescent thymine surrogate. Interestingly, when the diox T‐ containing strand was hybridized with a complementary strand, the duplex exhibited higher fluorescence than a single strand. diox T can be used for a broad range of applications in chemical biology. More information can be found in the Full Paper by S. Park, H. Sugiyama, et al. on page 9913.